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Side Effects of Extended-Release Lamotrigine
Most people do not experience any problems while taking extended-release lamotrigine. Side effects, however, are possible. In clinical trials, common reactions included dizziness, dry mouth, and weakness. If you develop any serious side effects while taking this medication, such as yellow skin or a worsening of your seizures, contact your healthcare provider right away.
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As with any medicine, side effects are possible with extended-release lamotrigine (Lamictal® XR™). However, not everyone who takes the medication will have problems. In fact, most people tolerate it quite well. If side effects do occur, in most cases, they are minor and either require no treatment or are treated easily by you or your healthcare provider.
(This article covers many, but not all, of the possible extended-release lamotrigine side effects. Your healthcare provider can discuss a more complete list with you.)
Some side effects with this medicine, while occurring infrequently, are potentially serious and should be reported to your healthcare provider. These include but are not limited to:
- Worsening of seizures
- Depression, anxiety, or suicidal thoughts
- Any unusual bruising or bleeding, which may be a sign of low blood platelets or anemia
- Signs of liver damage, such as yellow eyes or skin (jaundice)
- Severe muscle pain
- Frequent infections, which may be a sign of low white blood cells
- Signs of a dangerous allergic reaction, including:
- Hives or any rash
- Fever
- Swollen lymph nodes (swollen "glands")
- Painful sores in or around the mouth or eyes
- Swelling of the lips or tongue.
Extended-release lamotrigine (and the short-acting form of this medication, Lamictal®) can cause serious skin rashes and allergic reactions. These rashes can cause large sections of the skin to die and can cause disfigurement or even loss of life (for more information, see Lamictal Rash).
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD