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Side Effects of Extended-Release Lamotrigine

Common Side Effects

Extended-release lamotrigine has been studied thoroughly in clinical trials. In these studies, the side effects that occurred in a group of people taking extended-release lamotrigine in addition to their usual seizure medications were documented and compared to problems that occurred in another group of people taking their usual seizure medications plus a placebo (a "sugar pill" with no active ingredients).
This way, it is possible to see what extended-release lamotrigine side effects occurred, how often they appeared, and how they compared to the group taking the placebo.
Because extended-release lamotrigine was added to other seizure medications in these clinical studies and not used alone, the information from these studies probably does not accurately reflect the true incidence of side effects actually caused by extended-release lamotrigine.
In these studies, the most common side effects of extended-release lamotrigine (plus other seizure medications) included:
  • Dizziness -- in up to 19 percent of people
  • Fatigue, weakness, or malaise (a general ill feeling) -- up to 9 percent
  • Diarrhea -- up to 8 percent
  • Nausea -- up to 7 percent
  • Drowsiness -- up to 7 percent
  • Shakiness (tremor) -- up to 7 percent.
Other common reactions, occurring in 2 to 6 percent of people, included:
  • A spinning sensation (vertigo)
  • Blurred vision, double vision, or abnormal eye movements
  • Abdominal pain (stomach pain), vomiting, or constipation
  • Dry mouth
  • Chest pain
  • Changes in walking gait or balance problems
  • Pain
  • The flu or flu-like symptoms, such as a fever and chills
  • Sinus infection
  • Loss of appetite
  • Weight gain (see Lamictal XR and Weight Gain)
  • Muscle pain
  • Depression or anxiety
  • Throat pain, nosebleeds, or sinus congestion
  • Rashes, hair loss, or hot flashes.
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Lamotrigine XR Drug Information

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