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Drug Interactions With Extended-Release Lamotrigine
The seizure medicine extended-release lamotrigine can interact with a number of other drugs, including rifampin, phenytoin, and valproic acid. These interactions can decrease the effectiveness of your medications and increase your risk of side effects. To lower your risk of problems, be sure to tell your healthcare provider about any other medications you are taking.
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Extended-release lamotrigine (Lamictal® XR™) can potentially interact with a number of other medications. Some of the medicines that may lead to drug interactions with extended-release lamotrigine include:
- Carbamazepine (Carbatrol®, Epitol®, Equetro®, Tegretol®)
- Hormonal contraceptives (such as birth control pills) or hormone replacement therapy (HRT)
- Phenobarbital (Luminal®)
- Phenytoin (Dilantin®, Phenytek®)
- Primidone (Mysoline®)
- Rifampin (Rifadin®)
- Valproate medications, such as:
- Delayed release valproic acid (Stavzor®)
- Divalproex (Depakote®)
- Divalproex ER (Depakote® ER)
- Valproic acid (Depakene®).
The following sections explain in detail the potentially negative interactions that can occur when extended-release lamotrigine is combined with the medications listed above.
Carbamazepine
Carbamazepine can decrease the level of extended-release lamotrigine in your blood, perhaps making it less effective. Your healthcare provider may recommend a higher extended-release lamotrigine dosage if you are taking carbamazepine. In addition, using this medication may increase your risk of certain extended-release lamotrigine side effects, such as dizziness, vision problems, or coordination problems.
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD