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Drug Interactions With Extended-Release Lamotrigine

Oral Contraceptives or Hormone Replacement Therapy
Estrogen-containing medications, such as hormonal contraceptives (birth control pills, rings, or patches) or hormone replacement therapy (HRT), can decrease the level of extended-release lamotrigine in your blood, making it less effective.
 
This is especially problematic for cyclical birth control pills or hormone replacement medications that have a week of inactive pills to allow you to have your period, as the levels of extended-release lamotrigine in your blood will increase during the inactive pill week.
 
Talk to your healthcare provider about your birth control options; a nonhormonal method (such as condoms) may be best for your situation.
 
Phenobarbital
Phenobarbital can decrease the level of extended-release lamotrigine in your blood, possibly making it less effective. Your healthcare provider may recommend a higher dose of extended-release lamotrigine if you are taking phenobarbital, and may recommend decreasing this amount if you stop taking phenobarbital.
 
Phenytoin
Phenytoin may decrease the level of extended-release lamotrigine in your blood, perhaps making it less effective. Your healthcare provider may recommend a higher extended-release lamotrigine dose if you are taking phenytoin and may recommend decreasing it if you stop taking phenytoin.
 
Primidone
Primidone may decrease the level of extended-release lamotrigine in your blood, perhaps making it less effective. Your healthcare provider may recommend a higher dose of extended-release lamotrigine if you are taking primidone and may recommend decreasing this amount if you stop taking primidone.
 
Rifampin
Rifampin may decrease the level of extended-release lamotrigine in your blood, perhaps making it less effective. Your healthcare provider may recommend a higher extended-release lamotrigine dose if you are taking rifampin and may recommend decreasing it if you stop taking rifampin.
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