Drug Interactions With Ethosuximide

If ethosuximide is taken with certain other medications, such as some antibiotics or seizure medications, potentially negative interactions can occur. These drug interactions with ethosuximide can lead to problems such as increased or decreased drug levels in the blood. As a result, this may increase your risk for side effects or reduce the drugs' effectiveness. If drug interactions with ethosuximide are a concern, your healthcare provider may adjust your dosages.

 

An Overview of Drug Interactions With Ethosuximide

Ethosuximide (Zarontin®) can potentially interact with other medications, particularly other seizure medications. Some of these medicines that may lead to ethosuximide interactions include:
 
  • Certain antibiotics or antifungals, including:
o Clarithromycin (Biaxin®)
o Erythromycin (Ery-Tab®)
o Isoniazid (Nydrazid®)
o Itraconazole (Sporanox®)
o Ketoconazole (Nizoral®)
o Miconazole
o Telithromycin (Ketek®) 
  • Certain anticonvulsants, including:
o Carbamazepine (Carbatrol®, Epitol®, Equetro™, Tegretol®, Tegretol XR®)
o Fosphenytoin (Cerebyx®)
o Phenobarbital (Luminal®)
o Pentobarbital (Nembutal®)
  • Protease inhibitors, such as:
(Drug Interactions With Ethosuximide Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;