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Drug Interactions With Entacapone
Many medications can cause drug interactions with entacapone, including cholestyramine, monoamine oxidase inhibitors, and certain antibiotics. These medicines can affect the level of entacapone in your blood or increase your risk of side effects. To minimize your chance of developing entacapone drug interactions, tell your healthcare provider about all other medications you are taking before starting Parkinson's treatment.
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Entacapone (Comtan®) can potentially interact with several different medications. Some of the medicines that may lead to drug interactions with entacapone include:
- Certain antibiotics, such as:
- Ampicillin
- Chloramphenicol
- Erythromycin (Ery-Tab®)
- Rifampicin (Rifadin®)
- Cholestyramine (Prevalite®, Questran®, Questran® Light)
- Medications metabolized by catechol-O-methyltransferase (COMT), such as:
- Apomorphine (Apokyn®)
- Dobutamine
- Dopamine
- Epinephrine (Adrenalin®, EpiPen®, Primatene® Mist)
- Isoproterenol (Isuprel®)
- Methyldopa
- Norepinephrine (Levophed®)
- Monoamine oxidase inhibitors (MAOIs), such as:
- Isocarboxazid (Marplan®)
- Phenelzine (Nardil®)
- Rasagiline (Azilect®)
- Selegiline (Eldepryl®, Emsam®, Zelapar®)
- Tranylcypromine (Parnate®)
- Probenecid.
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD