Drug Interactions With Entacapone (Cont.)

More Information on Interactions With Entacapone Explained

The following sections explain in detail the potentially negative interactions that can occur when entacapone is combined with any of the drugs listed above.
 
Certain Antibiotics
Some antibiotics may affect the level of entacapone in your blood. Check with your healthcare provider before taking such medications together.
 
Cholestyramine (Prevalite, Questran, Questran Light)
Cholestyramine may affect the level of entacapone in your blood. Check with your healthcare provider before taking these medications together.
 
Medications Metabolized by COMT
Entacapone inhibits COMT (catechol-O-methyltransferase), an enzyme that breaks down certain drugs. Entacapone could significantly increase the level of such drugs in the body, possibly increasing the risk of dangerous side effects. Check with your healthcare provider before combining entacapone with such medications.
 
Monoamine Oxidase Inhibitors (MAOIs)
Non-selective MAOIs (isocarboxazid, phenelzine, and tranylcypromine) should not be combined with entacapone. Selective MAOI-B inhibitors (selegiline and rasagiline) can be used with entacapone, although the risk of low blood pressure may be increased.
 
Probenecid
Probenecid may affect the level of entacapone in your blood. Check with your healthcare provider before taking these medications together.
 

Final Thoughts on Drug Interactions With Entacapone

It is possible that not all drug interactions with entacapone were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about any specific drug interactions that may apply to you.
 

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;