• Heart problems of any kind, especially a history of heart disease, angina, an irregular heart rhythm, or a heart attack
• A history of stroke, transient ischemic attack (TIA or "mini-stroke"), or other bleeding in the brain (such as a subarachnoid hemorrhage)
• High blood pressure (hypertension)
• High cholesterol
• Certain blood vessel conditions, such as peripheral vascular disease, ischemic bowel disease, or Raynaud's phenomenon
• Diabetes
• Liver problems, including liver failure or cirrhosis
• Depression
• Gone through menopause
• Any allergies, including allergies to foods, dyes, or preservatives.
   

• Are pregnant or thinking of becoming pregnant (see Relpax and Pregnancy)
• Are breastfeeding
• Smoke
• Have a family history of heart disease.