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Eldepryl Warnings and Precautions

To help ensure a safe and effective treatment process with Eldepryl, warnings and precautions should be reviewed with your healthcare provider. For example, you may not be able to safely use Eldepryl if you have certain health conditions, such as liver or kidney disease. It is also important to tell your healthcare provider about any other medications you are taking before starting Eldepryl. Warnings and precautions also extend to women who are pregnant or breastfeeding.

Eldepryl: What Should I Tell My Healthcare Provider?

You should talk with your healthcare provider prior to taking Eldepryl® (selegiline hydrochloride) if you have:
  • Liver disease, such as liver failure, hepatitis, or cirrhosis
  • Kidney disease, such as kidney failure (renal failure)
  • Any allergies, including allergies to foods, dyes, or preservatives.
Also, let your healthcare provider know if you are:
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
Make sure to tell your healthcare provider about any medications you are taking, including prescription and non-prescription medicines, vitamins, and herbal supplements.

Specific Eldepryl Warnings and Precautions

Some of the warnings and precautions to be aware of prior to taking Eldepryl include the following:
  • Eldepryl can cause hypertensive crisis, which is a life-threatening increase in blood pressure. Tell your healthcare provider right away if you have symptoms of a hypertensive crisis, such as:


    • Headaches
    • Feelings of a rapidly or forcefully beating heart (palpitations)
    • A sore or stiff neck
    • Nausea or vomiting
    • Sweating, with a high fever (or sometimes with cold, clammy skin)
    • Sensitivity to light
    • A rapid heart rate (tachycardia) or low heart rate (bradycardia)
    • Chest pain or throat tightness
    • Dilated (wide open) pupils. 


  • Eldepryl has several potentially lethal drug interactions. In order to take Eldepryl safely, you must commit to avoiding many medications, including several non-prescription medications. Always check with your healthcare provider before taking any medications with Eldepryl (see Eldepryl Drug Interactions for more information).
  • Eldepryl should not be taken at doses higher than 10 mg per day. Although no special diet is required for normal Eldepryl doses, higher doses of Eldepryl interact dangerously with many foods.
  • Taking Eldepryl with levodopa medications (such as Sinemet®, Sinemet® CR, Parcopa®, or Stalevo®) can increase the risk of involuntary muscle movements called dyskinesia. Although not typically dangerous, dyskinesia is usually quite disturbing and intolerable. If you develop a severe dyskinesia while taking Eldepryl and levodopa, your healthcare provider may need to decrease your levodopa dosage.
  • The liver and kidneys help to remove Eldepryl from the body. Eldepryl has not been adequately studied in people with liver or kidney disease.
  • Eldepryl can cause low blood pressure (hypotension). Let your healthcare provider know if you develop signs of low blood pressure, such as dizziness, fainting, or lightheadedness.
  • Eldepryl tablets contain phenylalanine, an amino acid. This is important for people with phenylketonuria, who must limit their intake of phenylalanine.
  • Eldepryl tablets can cause mouth irritation and sores.
  • Eldepryl can cause hallucinations (seeing, feeling, tasting, smelling, or hearing things that aren't really there). Let your healthcare provider know if you think you may be hallucinating.
  • Studies have suggested that people who take Parkinson's medications (including Eldepryl) may have a higher risk of malignant melanoma (a type of skin cancer). However, it is not clear if this truly is a problem, as this may simply reflect the fact that people with Parkinson's have a higher risk of melanoma than normal.
  • Eldepryl is considered a pregnancy Category C medication. This means that it may not be safe for use during pregnancy, although the full risks are not known (see Eldepryl and Pregnancy).
  • It is not known if Eldepryl passes through breast milk. Therefore, if you are breastfeeding or plan to start breastfeeding, discuss this with your healthcare provider prior to taking the drug (see Eldepryl and Breastfeeding).
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Eldepryl Medication Information

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