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Eldepryl Drug Interactions
There are numerous medications that can cause potentially serious side effects when they are combined with Eldepryl. Drug interactions can occur when Eldepryl is taken with certain medications, including some antidepressants, stimulants, and allergy products. Some of these interactions can cause dangerously high blood pressure, seizures, or other problems. To avoid these complications, talk to your healthcare provider about drug interactions with Eldepryl that may apply to you.
Eldepryl® (selegiline hydrochloride) can potentially interact with many medicines. Because there are so many Eldepryl drug interactions that are extremely dangerous, it is important to check with your healthcare provider before taking any medication, including prescription and non-prescription medications. Make sure to tell all your healthcare providers (including dentists and surgeons) that you are taking Eldepryl. Some of the medicines that may lead to Eldepryl interactions include:
- Apraclonidine (Iopidine®)
- Atomoxetine (Strattera®)
- Brimonidine (Alphagan® P, Combigan™)
- Buspirone (BuSpar®)
- Cyclobenzaprine (Flexeril®)
- Entacapone (Comtan®, Stalevo®)
- Levodopa medications (Parcopa®, Sinemet®, Sinemet® CR, Stalevo®)
- Many cough, cold, and allergy products, such as:
- Dextromethorphan (Robitussin DM® and many others)
- Naphazoline (various nasal and eye drops, such as Visine-A®)
- Oxymetazoline (various nasal and eye drops, such as Afrin®)
- Phenylephrine (Sudafed PE® and many others)
- Propylhexedrine (Benzedrex®)
- Pseudoephedrine (Sudafed® and many others)
- Meperidine (Demerol®)
- Methadone (Dolophine®, Methadose®)
- Miscellaneous antidepressants, such as:
- Bupropion (Aplenzin™, Budeprion XL®, Budeprion™ SR, Buproban®, Forfivo™ XL, Wellbutrin SR®, Wellbutrin XL®, Wellbutrin®, Zyban®)
- Mirtazapine (Remeron®)
- Nefazodone (Serzone®)
- Trazodone (Desyrel®) or trazodone ER (Oleptro™)
- Vilazodone (Viibryd™)
- Other monoamine oxidase inhibitors (MAOIs), including:
- Isocarboxazid (Marplan®)
- Phenelzine (Nardil®)
- Rasagiline (Azilect®)
- Other forms of selegiline hydrochloride (Eldepryl®, Emsam®)
- Tranylcypromine (Parnate®)
- Propoxyphene medications (Balacet™, Darvon®, Darvocet®)
- "Pressor" medications, including:
- Dopamine
- Ephedrine
- Epinephrine (Adrenalin®, EpiPen®)
- Isometheptene (Duradrin®, Midrin®, Migquin®, Migratine®, Migrazone®, Migrin-A®)
- Levonordefrin (Carbocaine with Neo-Cobefrin®)
- Midodrine (Orvaten®, ProAmatine®)
- Norepinephrine (Levophed®)
- Sibutramine (Meridia®)
- SSRI or SNRI antidepressants, including:
- Citalopram (Celexa®)
- Duloxetine (Cymbalta®)
- Desvenlafaxine (Pristiq™)
- Escitalopram (Lexapro®)
- Fluoxetine (Prozac®, Sarafem®)
- Fluvoxamine (Luvox®, Luvox® CR)
- Paroxetine (Paxil®, Paxil CR®)
- Sertraline (Zoloft®)
- Venlafaxine (Effexor®, Effexor XR®)
- Stimulants, such as:
- Amphetamine and dextroamphetamine (Adderall®, Adderall XR®)
- Benzphetamine (Didrex®)
- Dexmethylphenidate (Focalin®, Focalin XR®)
- Dextroamphetamine (Dexedrine®, Dexedrine Spansules®)
- Methamphetamine (Desoxyn®)
- Methylphenidate (Concerta®, Daytrana®, Metadate CD®, Metadate ER®, Methylin®, Ritalin®, Ritalin LA®, Ritalin SR®)
- Phentermine (Adipex-P®, Ionamin®)
- St. John's wort
- Tolcapone (Tasmar®)
- Tramadol (Rybix™ ODT, Ryzolt®, Ultram®, Ultram® ER) or tramadol/acetaminophen (Ultracet®)
- Tricyclic antidepressants, including:
- Amitriptyline (Elavil®)
- Amitriptyline and chlordiazepoxide (Limbitrol®)
- Amitriptyline and perphenazine (Etrafon®)
- Amoxapine (Asendin®)
- Clomipramine (Anafranil®)
- Desipramine (Norpramin®)
- Doxepin (Sinequan®, Silenor®)
- Imipramine (Tofranil®)
- Maprotiline (Ludiomil®)
- Nortriptyline (Pamelor®)
- Protriptyline (Vivactil®)
- Trimipramine (Surmontil®)
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD