Side Effects of Divalproex ER

A few of the most common side effects of divalproex ER that were seen in clinical studies include indigestion or heartburn, vomiting, and drowsiness. Some less common side effects, occurring in less than 5 percent of people, included shakiness, a dry mouth, and weight gain. While most divalproex ER side effects are minor, some may require medical attention. These serious side effects can include signs of pancreatitis, worsening of seizures, and depression.

An Introduction to Divalproex ER Side Effects

As with any medicine, side effects are possible with divalproex ER (Depakote ER®); however, not everyone who takes the medication will experience side effects. In fact, most people tolerate divalproex ER quite well. If side effects do occur, in most cases they are minor and either require no treatment or can easily be treated by you or your healthcare provider.
 
(This article covers many, but not all, of the possible side effects with divalproex ER. Your healthcare provider can discuss a more complete list of divalproex ER side effects with you.)
 

Common Side Effects With Divalproex ER

Divalproex ER has been studied thoroughly in clinical trials. In these studies, the side effects that occur in a group of people taking the drug are documented and are then compared to side effects that occur in another group of people not taking the medicine. This way, it is possible to see what side effects occur, how often they appear, and how they compare to the group not taking the medicine.
 
In these studies, some of the most common side effects of divalproex ER included:
 
  • Drowsiness -- in up to 26 percent of people
  • Indigestion or heartburn -- up to 23 percent
  • Nausea -- up to 19 percent
  • Infections -- up to 15 percent
  • Vomiting -- up to 13 percent.
     
Some other common side effects, occurring in 6 percent to 12 percent of people, included:
 
  • Diarrhea
  • Dizziness
  • Pain
  • Abdominal pain (or stomach pain)
  • Accidental injury
  • Weakness
  • A sore throat.
     

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(Side Effects of Divalproex ER Continued: Page 2)
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;
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