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Drug Interactions With Divalproex ER
A number of medications should be used cautiously with divalproex ER. Drug interactions may occur if divalproex ER is taken together with lamotrigine, warfarin, aspirin, or topiramate, among other drugs. Drug interactions with divalproex ER may potentially affect the levels of some drugs in your blood, which can decrease the effectiveness of the medications or increase your risk of developing side effects.
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Divalproex ER (Depakote ER®) can potentially interact with many other medications. Some of these medicines that may lead to divalproex ER interactions include:
- Amitriptyline (Elavil®)
- Aspirin
- Carbamazepine (Epitol®, Equetro™, Tegretol®, Tegretol XR®)
- Carbapenem antibiotics, such as:
- Doripenem (Doribax™)
- Ertapenem (Invanz®)
- Imipenem and cilastatin (Primaxin®)
- Meropenem (Merrem®)
- Clonazepam (Klonopin®)
- Diazepam (Valium®)
- Ethosuximide (Zarontin®)
- Felbamate (Felbatol®)
- Lamotrigine (Lamictal®)
- Nortriptyline (Pamelor®)
- Phenobarbital (Luminal®)
- Phenytoin (Dilantin®, Phenytek®)
- Primidone (Mysoline®)
- Rifampin (Rifadin®)
- Tolbutamide (Orinase®)
- Topiramate (Topamax®)
- Warfarin (Coumadin®, Jantoven®)
- Zidovudine (Retrovir®).
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD