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Drug Interactions With Divalproex ER

Ethosuximide (Zarontin)
Divalproex ER can raise the amount of ethosuximide in your blood, increasing your risk of side effects. Your healthcare provider may need lower your ethosuximide dosage.
 
Felbamate (Felbatol)
Felbamate can raise the amount of divalproex ER in your blood, increasing your risk of side effects. Your healthcare provider may need to measure the level of divalproex ER in your blood and adjust your dose as necessary.
 
Lamotrigine (Lamictal)
Divalproex ER can raise the amount of lamotrigine in your blood, increasing your risk of side effects. Your healthcare provider may need to lower your lamotrigine dosage.
 
Nortriptyline (Pamelor)
Divalproex ER can increase the level of nortriptyline in your blood, increasing your risk of nortriptyline side effects. Your healthcare provider may need to decrease your nortriptyline dosage.
 
Phenobarbital (Luminal)
Taking phenobarbital with divalproex ER can decrease the level of divalproex ER in your blood, perhaps making it less effective. Taking these medications together may also raise the level of phenobarbital in your blood, increasing your risk of side effects. Your healthcare provider will monitor you more closely and adjust your doses of these medications if necessary.
 
Phenytoin (Dilantin, Phenytek)
Taking phenytoin with divalproex ER can decrease the level of divalproex ER in your blood, perhaps making it less effective. Taking these medications together may also raise the level of phenytoin in your blood, increasing your risk of side effects. Your healthcare provider will monitor you more closely and adjust your doses of these medications if necessary.
 
Primidone (Mysoline)
Taking primidone with divalproex ER can decrease the level of divalproex ER in your blood, perhaps making it less effective. Taking these medications together may also raise the level of primidone in your blood, increasing your risk of side effects. Your healthcare provider will monitor you more closely and adjust your doses of these medications if necessary.
Know the Signs - Concussion Safety

Divalproex Extended Release

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