Drug Interactions With Divalproex ER (Cont.)

Interactions With Divalproex ER Explained

The following sections explain in detail the potentially negative interactions that can occur when divalproex ER is combined with any of the drugs listed above.
 
Amitriptyline (Elavil)
Divalproex ER can raise the level of amitriptyline in your blood, increasing your risk of amitriptyline side effects. Your healthcare provider may need to decrease your amitriptyline dosage.
 
Aspirin
Aspirin may affect the way your body handles divalproex ER, perhaps increasing your risk of side effects. Your healthcare provider will need to monitor you more closely and adjust your divalproex ER dosage as necessary.
 
Carbamazepine (Epitol, Equetro, Tegretol, Tegretol XR)
Taking carbamazepine with divalproex ER can decrease the level of divalproex ER in your blood, perhaps making it less effective. Taking these medications together may also affect the way your body handles carbamazepine, increasing your risk of side effects. Your healthcare provider will monitor you more closely and adjust your doses of these medications if necessary.
 
Carbapenem Antibiotics
Carbapenem antibiotics may decrease the level of divalproex ER in your blood, perhaps making it less effective. Your healthcare provider may need to adjust your divalproex ER dosage.
 
Clonazepam (Klonopin)
Combining clonazepam with divalproex ER can increase your risk of absence seizures, especially if you have had absence seizures before. Talk with your healthcare provider before taking these medications together.
 
Diazepam (Valium)
Divalproex ER can raise the level of diazepam in your blood, increasing your risk of diazepam side effects. Your healthcare provider may need to decrease your diazepam dosage.
(Drug Interactions With Divalproex ER Continued: Page 3)

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;