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What Is Dimethyl Fumarate Used For?

How Does Dimethyl Fumarate Work?

At this time, it is not entirely clear how dimethyl fumarate works to treat multiple sclerosis. It may work in a couple of ways.
Dimethyl fumarate activates a protein known as nuclear factor (erythroid-derived 2)-like 2 (Nrf2). This protein is involved in protecting cells from the negative effects of oxidative stress. Oxidative stress is a term used to describe the cumulative damage to the body by the production of harmful chemicals produced during many normal body functions. Oxidative stress is thought to be involved in damage to myelin and nerves in MS.
Dimethyl fumarate may also have anti-inflammatory effects, which can help reduce damage to myelin that occurs in people with MS.

Can Children Use It?

Dimethyl fumarate has not been adequately studied in children. At this point, the drug is only approved for use in adults 18 years of age and older. Talk to your child's healthcare provider about the risks and benefits of using this medication in your child. 

Is It Safe for Older Adults?

Clinical studies of dimethyl fumarate did not include enough people 65 years of age and older to determine whether this age group would respond to the medication any differently than younger adults. Dimethyl fumarate can be used in older adults; however, until more information is known, it should probably be used cautiously in such people.

What About Off-Label DImethyl Fumarate Uses?

On occasion, your healthcare provider may recommend this medicine for treating something other than multiple sclerosis. This is called an "off-label" use. At this time, there are no well-accepted off-label uses for dimethyl fumarate.  
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Dimethyl Fumarate Drug Information

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