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Dimethyl Fumarate Side Effects

Common Side Effects

Dimethyl fumarate has been studied extensively in clinical trials. In these studies, the side effects that occurred in a group of people taking the drug were documented and compared to those that occurred in a similar group of people taking a placebo (a "sugar pill" with no active ingredients). As a result, it was possible to see what side effects occurred, how often they appeared, and how they compared to the placebo.
 
In these studies, the most common dimethyl fumarate side effects included:
 
  • Flushing (redness, warmth, itching, or burning sensations) -- in up to 40 percent of people
  • Abdominal (stomach) pain -- up to 18 percent
  • Diarrhea -- up to 14 percent
  • Nausea -- up to 12 percent
  • Vomiting -- up to 9 percent
  • Itching -- up to 8 percent
  • Rash -- up to 8 percent.
 
Other common reactions, occurring in 2 percent to 6 percent of people, included:
 
  • The presence of albumin (a protein) in the urine, which could be a sign of kidney damage
  • Redness of the skin
  • Heartburn or indigestion
  • Increased liver enzymes
  • A decrease in white blood cell counts.
 

Final Thoughts

You may experience some or none of the side effects listed in this article. Unfortunately, there is no way for your healthcare provider to know beforehand if you will have problems with a medicine that you have never tried.
 
Therefore, make sure to let your healthcare provider know if you develop any adverse reactions while using the drug or if something "just does not seem right." While it may not be a side effect of dimethyl fumarate, your healthcare provider will be able to diagnose and treat the problem.
 
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Dimethyl Fumarate Drug Information

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