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Drug Interactions With Diazepam Rectal Gel
Some of the medications that can lead to drug interactions with diazepam rectal gel include anesthetics, antidepressants, and antipsychotic medications. These interactions can lead to an increased risk of side effects, such as drowsiness, confusion, memory problems, and difficulty breathing. To avoid these complications, be sure to talk with your pharmacist or healthcare provider about the drug interactions with diazepam rectal gel that may apply to you.
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Diazepam rectal gel (Diastat®) can potentially interact with other medications. Some of the medicines that may lead to drug interactions with diazepam rectal gel include:
- Alcohol
- Anesthetics
- Antidepressant medications
- Antipsychotic medications, such as:
- Aripiprazole (Abilify®)
- Asenapine (Saphris®)
- Chlorpromazine (Thorazine®)
- Clozapine (Clozaril®, FazaClo®)
- Fluphenazine (Prolixin®)
- Haloperidol (Haldol®)
- Iloperidone (Fanapt®)
- Loxapine (Adasuve™, Loxitane®)
- Lurasidone (Latuda®)
- Molindone (Moban®)
- Olanzapine (Zyprexa®, Symbyax®)
- Paliperidone (Invega®)
- Perphenazine (Trilafon®)
- Pimozide (Orap®)
- Prochlorperazine (Compazine®, Compro®)
- Quetiapine (Seroquel®)
- Risperidone (Risperdal®)
- Thioridazine (Mellaril®)
- Thiothixene (Navane®)
- Trifluoperazine (Stelazine®)
- Ziprasidone (Geodon®)
- Barbiturates, including:
- Amobarbital (Amytal®)
- Butalbital (Fioricet®, Fiorinal®)
- Pentobarbital (Nembutal®)
- Phenobarbital (Luminal®)
- Secobarbital (Seconal®)
- Narcotics or opiates, such as morphine, oxycodone (OxyContin®), or hydrocodone (Lortab®, Vicodin®)
- Other benzodiazepines, including:
- Alprazolam (Xanax®)
- Chlordiazepoxide (Librium®, Limbitrol®, Librax®)
- Clobazam (Onfi™)
- Clonazepam (Klonopin®)
- Clorazepate (Tranxene®)
- Estazolam (ProSom®)
- Flurazepam (Dalmane®)
- Lorazepam (Ativan®)
- Midazolam (Versed®)
- Temazepam (Restoril®)
- Triazolam (Halcion®)
- Other seizure medications
- Sleep medications.
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD