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What Is Dantrolene Used For?

How Does This Medicine Work?

Dantrolene belongs to a group of medicines known as muscle relaxants. However, unlike other muscle relaxants, dantrolene works directly on the muscle. It is thought to work by interfering with calcium release from calcium storage sites in the muscles known as sarcoplasmic reticulum. The sarcoplasmic reticulum release calcium during muscle contractions. By interfering with calcium release, dantrolene causes the muscles to relax.
 

Can Children Use It?

Dantrolene capsules are approved for use in children five years of age or older. The injection is approved for use in children of all ages.
 

Is It Safe for Older Adults to Use Dantrolene?

Dantrolene can be used in older adults. However, there were not enough people over the age of 65 in clinical studies to determine if this age group would respond any differently to dantrolene than younger age groups. Because older adults may be more sensitive to the effects of this medication, they may need to be monitored more closely. Lower initial doses may also be needed.
 

What About Off-Label Dantrolene Uses?

On occasion, your healthcare provider may recommend this medicine for something other than the conditions discussed in this article. This is called an "off-label" use. Some of the possible off-label uses of dantrolene include but are not limited to the treatment of:
 
  • Neuroleptic malignant syndrome
  • Tetanus
  • Heat stroke
  • Exercise-induced muscle pain.
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Dantrolene Drug Information

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