Drug Interactions With Dantrolene
CYP 3A4 Inhibitor Medications
The liver breaks down dantrolene using enzymes known as CYP 3A4 enzymes, and medications known as CYP 3A4 inhibitors can decrease the activity of these enzymes. Thus, combining dantrolene with one of these drugs may increase the level of dantrolene in your bloodstream, increasing your risk for side effects. Your healthcare provider may monitor you more closely for side effects if you use these medications together.
The risk for liver failure from dantrolene seems to be higher in women over the age of 35 who also took estrogen. Therefore, you should talk to your healthcare provider about this potential interaction if you are on estrogen therapy.
Medications That Cause Drowsiness
Dantrolene has the potential to cause significant drowsiness. Taking it with other medications that cause drowsiness may further increase the risk. This may affect your ability to drive or perform other activities that require mental alertness. Check with your healthcare provider before using dantrolene with other medications that can cause drowsiness.
Combining dantrolene with metyrosine can increase your risk for severe drowsiness. This may affect your ability to drive or perform other activities that require mental alertness.
Dantrolene may increase the muscle-relaxing effects of vecuronium. Your healthcare provider will carefully monitor you if you combine these medicines.