Drug Interactions With Dantrolene
More Detail on Drug Interactions With DantroleneThe following sections explain in detail the potentially negative interactions that can occur when dantrolene is combined with any of the drugs listed above.
Combining alcohol with dantrolene can increase your risk for central nervous system (CNS) depression (low activity of the CNS). Because the CNS controls much of the body's activities, CNS depression can lead to serious problems, such as a slowed heart rate and breathing, severe drowsiness, and problems thinking and moving. It is best to avoid alcohol during dantrolene treatment.
Combining azelastine with dantrolene could potentially increase your risk for CNS depression, which could cause serious side effects, such as slowed heart rate and breathing, severe drowsiness, and problems thinking and moving. It is generally recommended that these medicines not be used together. It should be noted, however, that this interaction is not likely to be a problem with azelastine ophthalmic solution (Optivar®).
Calcium Channel Blockers
There have been rare reports of serious heart problems, including reduced cardiac output (when the heart is unable to pump out enough blood to the body), occurring in people who received dantrolene in combination with calcium channel blockers. This interaction has only been reported in people given dantrolene intravenously (as an injection into a vein). Talk to your healthcare provider about this potential interaction if you take a calcium channel blocker.
CYP 3A4 Inducer Medications
The liver breaks down dantrolene using enzymes known as CYP 3A4 enzymes, and medications known as CYP 3A4 inducers can increase the activity of these enzymes. Thus, combining dantrolene with one of these drugs may decrease the level of dantrolene in your bloodstream, potentially making it less effective. Your healthcare provider may need to monitor you more closely, and possibly adjust your dose, if you use these drugs together.