Dantrolene comes as a capsule that is taken by mouth three to four times a day and as an injection that is given slowly into a vein. A person's individualized dose of dantrolene will be based on his or her response to the drug and other medications being taken, among other factors. This prescription medicine can be given to adults as well as children.
An Introduction to Your Dosage of DantroleneThe dose of dantrolene sodium (Dantrium®) your healthcare provider recommends will vary, depending on a number of factors, including:
- Whether you are taking the medicine by mouth or receiving it as an injection
- Why you are using the medicine
- Your age
- Your weight
- How you respond to dantrolene.
As is always the case, do not adjust your dosage unless your healthcare provider specifically tells you to do so.
Recommended Dantrolene Dosing Guidelines for Chronic SpasticityThe standard initial dantrolene dosage for relieving muscle spasms and stiffness in adults is 25 mg once a day for seven days, followed by 25 mg three times a day. Your healthcare provider may increase your amount, if needed, to control your symptoms by increasing your dose first to 50 mg three times a day for seven days and then, if necessary, to 100 mg three times a day.
The standard initial dose of dantrolene for relieving muscle spasms and stiffness in children is 0.5 mg per kg body weight (about 0.23 mg per lb) once a day for seven days, followed by 0.5 mg per kg three times a day. Your child's healthcare provider may further increase your child's dose, if needed, to control symptoms by first increasing the dose to 1 mg per kg (about 0.45 mg per lb) three times a day for seven days and then, if necessary, to 2 mg per kg (about 0.91 mg per lb) three times a day.
Each dose should be tried for at least seven days before the amount is further increased. This is because it may take seven days to see a complete response. If a response is not observed, the amount should be lowered to the previous dose that was effective.
Some people may need higher dantrolene doses than those listed here, or may need to take the medicine four times a day. The maximum recommended dosage is 100 mg four times a day.