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Dantrolene Dosage

What Is the Recommended Dantrolene Dosage for Malignant Hyperthermia?

Dantrolene may be used to prevent or treat malignant hyperthermia. The medication may also be used after malignant hyperthermia has occurred to prevent symptoms from recurring.
 
Prevention Dose
The usual recommended dose of oral dantrolene (dantrolene capsules) to prevent malignant hyperthermia is 4 to 8 mg per kg per day (about 1.82 to 3.64 mg per lb per day) divided into three or four smaller doses per day. This is normally given starting one to two days before surgery, with the final dose given three to four hours before surgery.
 
The usual recommended dose of dantrolene injection to prevent malignant hyperthermia is 2.5 mg per kg (about 1.14 mg per lb) given slowly into a vein over about an hour (an intravenous, or IV, infusion). The dose is normally started about 75 minutes before surgery. Additional doses may be needed during surgery if signs of malignant hyperthermia develop. If necessary, your healthcare provider will determine the amount you need during surgery.
 
Treatment Dose
The usual recommended dose of dantrolene injection to treat an episode of malignant hyperthermia is at least 1 mg per kg body weight (0.45 mg per lb) given as a rapid injection into a vein (an intravenous, or IV, push). Additional doses will be given until symptoms have subsided or a total of 10 mg per kg (4.54 mg per lb) has been given.
 

Post-Malignant Hyperthermia Follow-Up Treatment

The usual recommended dose of oral dantrolene (dantrolene capsules) after an episode of malignant hyperthermia and to prevent a recurrence is 4 to 8 mg per kg per day (about 1.82 to 3.64 mg per lb per day), divided into four smaller doses per day. This dose is normally given for one to three days. If oral dantrolene cannot be used, the drug may be given as an injection. The minimum dose in this case is normally 1 mg per kg (about 0.45 mg per lb); however, amounts are highly individualized and can vary from person to person.
 
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Dantrolene Drug Information

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