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Precautions and Warnings With Clobazam

You may have an increased risk for breathing difficulties, suicidal thoughts, or physical or psychological dependence while taking clobazam. This medicine can also interfere with a wide variety of medications and may not be safe for people who have depression, certain allergies, or a history of substance abuse. Other safety precautions and warnings with clobazam apply to women who are pregnant or breastfeeding.

What Should I Tell My Healthcare Provider Before Taking Clobazam?

Talk with your healthcare provider prior to taking clobazam (Onfi™) if you have:
 
  • A history of drug or alcohol abuse
  • Depression
  • Breathing problems
  • Any allergies, including to foods, dyes, or preservatives.
 
Also, let your healthcare provider know if you are:
 
  • Pregnant or thinking of becoming pregnant
  • Breastfeeding.
 
You should also tell your healthcare provider about all other medications you are taking, including prescription and nonprescription medicines, vitamins, and herbal supplements.
 

Specific Clobazam Warnings and Precautions

Some warnings and precautions to be aware of prior to taking this medicine include the following:
 
  • Studies suggest that seizure medications may increase the risk for suicide. Make sure to watch for any unusual behaviors or mood changes, and be sure your family and friends know to keep an eye out for such problems.
 
  • Clobazam is a controlled substance, which means it has the potential to be abused. There are special rules and regulations for prescribing and dispensing clobazam. This medicine should be used with caution in people with a history of alcohol or drug abuse.
  • Clobazam can cause extremely dangerous reactions that often start with a skin rash. Report any rash in a person taking this drug to a doctor immediately, unless it is very clear that the rash is caused by something else. Be especially vigilant for rashes in the first eight weeks of treatment.
 
  • Because clobazam can cause physical and psychological dependence, you should not stop taking the drug suddenly without first discussing it with your healthcare provider. He or she can gradually decrease your dosage over several weeks to help wean you off the medication.
 
  • Clobazam can cause severe drowsiness and difficulty breathing, which can be fatal. This risk is increased when clobazam is combined with alcohol, narcotics, or other medications or substances that cause drowsiness and sedation (see Drug Interactions With Clobazam for more information). You should not drive or operate heavy machinery until you know how this drug will affect you.
 
  • Clobazam is a pregnancy Category C medication. This means that it may not be safe for use during pregnancy, although the full risks are currently unknown (see Onfi and Pregnancy).
 
  • Clobazam passes through human breast milk. Therefore, if you are breastfeeding or plan to start, discuss this with your healthcare provider prior to taking the drug (see Onfi and Breastfeeding).
 
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Clobazam Drug Information

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