Drug Interactions With Clobazam
More Detail on Drug Interactions With ClobazamThe following sections explain in detail the potentially negative reactions that can occur when clobazam is combined with any of the drugs listed above.
Alcohol increases the level of clobazam in the blood by approximately 50 percent. Alcohol should be avoided while you are taking this medication.
CYP 2C19 Inhibitors
The liver breaks down clobazam using certain enzymes known as CYP 2C19 enzymes. Medications known as CYP 2C19 inhibitors decrease the activity of these enzymes, potentially increasing the level of clobazam in the blood. If you must take clobazam with one of these medications, your clobazam dosage may need to be reduced.
Hormonal Birth Control
Clobazam can decrease the level of birth control hormones in the blood, perhaps increasing your risk of pregnancy. If you take clobazam, an additional nonhormonal method of birth control, such as condoms, is recommended.
Other Medications That Cause Drowsiness
Clobazam has a tendency to cause drowsiness. Combining clobazam with other medications that cause drowsiness could potentially cause serious problems, such as extreme drowsiness, confusion, memory loss, or difficulty breathing.