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Drug Interactions With Carbidopa-Levodopa
Several medicines may cause negative drug interactions with carbidopa-levodopa, including antipsychotic medications, blood pressure medications, and tricyclic antidepressants. Some of these interactions can increase or decrease drug levels in your blood, which could increase your risk for side effects or decrease the medications' effectiveness. If drug interactions with carbidopa-levodopa are a concern, talk to your healthcare provider before starting any other medications.
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Carbidopa-levodopa (Sinemet®) can potentially interact with several different medications. Some of the medicines that may lead to drug interactions with carbidopa-levodopa include:
- Antipsychotic medications, such as:
-
Lurasidone (Latuda®)
-
Prochlorperazine (Compazine®, Compro®)
- Blood pressure medications
- Iron
- Isoniazid
- Metoclopramide (Reglan®)
- Monoamine oxidase inhibitors (MAOIs), such as:
- Isocarboxazid (Marplan®)
- Phenelzine (Nardil®)
- Rasagiline (Azilect®)
- Selegiline (Eldepryl®, Emsam®, Zelapar®)
- Tranylcypromine (Parnate®)
- Phenytoin (Dilantin®, Phenytek®)
- Tricyclic antidepressants, such as:
- Amitriptyline (Elavil®)
- Amoxapine (Asendin®)
- Clomipramine (Anafranil®)
- Desipramine (Norpramin®)
- Doxepin (Sinequan®)
- Imipramine (Tofranil®, Tofranil PM®)
- Maprotiline (Ludiomil®)
- Nortriptyline (Pamelor®)
- Protriptyline (Vivactil®)
- Trimipramine (Surmontil®).
Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD