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Drug Interactions With Carbidopa-Levodopa

More Information on Interactions With Carbidopa-Levodopa

The following sections explain in detail the potentially negative interactions that can occur when carbidopa-levodopa is combined with any of the drugs listed above.
 
Antipsychotic Medications
Antipsychotic medications can make carbidopa-levodopa less effective. Check with your healthcare provider before taking these medications together.
 
Blood Pressure Medications
Taking carbidopa-levodopa and a high blood pressure medication together can increase the risk of low blood pressure (hypotension). Check with your healthcare provider, as you may need a lower dose of your blood pressure medicine.
 
Iron
Iron can decrease the absorption of carbidopa-levodopa into the body, perhaps making it less effective. Iron products should be taken at least two hours before or after any carbidopa-levodopa dosage.
 
Isoniazid
Isoniazid can make carbidopa-levodopa less effective. Check with your healthcare provider before taking these medications together.
 
Metoclopramide (Reglan)
Metoclopramide can make carbidopa-levodopa less effective. However, the medication may also increase the absorption of carbidopa-levodopa into the body, which could make it more effective or increase the risk of side effects of carbidopa-levodopa. It is difficult to predict what exactly may happen if these medications are combined. Check with your healthcare provider before taking these medications together.
 
Monoamine Oxidase Inhibitors (MAOIs)
Non-selective MAOIs (isocarboxazid, phenelzine, and tranylcypromine) should not be combined with Sinemet or taken within two weeks of using carbidopa-levodopa. Selective MAOI-B inhibitors (selegiline and rasagiline) can be used with carbidopa-levodopa, although it may increase the risk of low blood pressure.
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Information on Carbidopa-Levodopa

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