Drug Interactions With Carbidopa-Levodopa-Entacapone (Cont.)

 
Metoclopramide (Reglan)
Metoclopramide can make carbidopa-levodopa-entacapone less effective. However, metoclopramide may also increase the absorption of carbidopa-levodopa-entacapone into the body, which could make it more effective or increase the risk of carbidopa-levodopa-entacapone side effects. It is difficult to predict what exactly may happen if these medications are combined. Check with your healthcare provider before taking these medications together.
 
Monoamine Oxidase Inhibitors (MAOIs)
Non-selective MAOIs (isocarboxazid, phenelzine, and tranylcypromine) should not be combined with carbidopa-levodopa-entacapone. Selective MAOI-B inhibitors (selegiline and rasagiline) can be used with carbidopa-levodopa-entacapone, although the risk of low blood pressure may be increased.
 
Phenytoin (Dilantin, Phenytek)
Phenytoin can make carbidopa-levodopa-entacapone less effective. Check with your healthcare provider before taking these medications together.
 
Probenecid
Probenecid may affect the level of entacapone (one of the components of carbidopa-levodopa-entacapone) in your blood. Check with your healthcare provider before taking these medications together.
 
Tricyclic Antidepressants
There have been reports of occasional problems, such as high blood pressure or involuntary body movements, when a tricyclic antidepressant was combined with carbidopa-levodopa (two of the components of carbidopa-levodopa-entacapone). Check with your healthcare provider before combining carbidopa-levodopa-entacapone with a tricyclic antidepressant.
 

Final Thoughts on Drug Interactions With Carbidopa-Levodopa-Entacapone

It is possible that not all drug interactions with carbidopa-levodopa-entacapone were discussed in this article. Therefore, you should talk with your pharmacist or healthcare provider about any specific drug interactions that may apply to you.
 

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;