Drug Interactions With Carbidopa-Levodopa-Entacapone (Cont.)

More Information on Interactions With Carbidopa-Levodopa-Entacapone

The following sections explain in detail the potentially negative interactions that can occur when carbidopa-levodopa-entacapone is combined with any of the drugs listed above.
 
Antipsychotic Medications
Antipsychotics can make carbidopa-levodopa-entacapone less effective. Check with your healthcare provider before taking these medications together.
 
Blood Pressure Medications
Taking carbidopa-levodopa-entacapone and a high blood pressure medication together can increase the risk of low blood pressure (hypotension). Check with your healthcare provider, as the dose of your blood pressure medicine may need to be reduced.
 
Certain Antibiotics
Some antibiotics may affect the level of entacapone (one of the components of carbidopa-levodopa-entacapone) in your blood. Check with your healthcare provider before taking such medications together.
 
Cholestyramine (Prevalite, Questran, Questran Light)
Cholestyramine may affect the level of entacapone (one of the components of carbidopa-levodopa-entacapone) in your blood. Check with your healthcare provider before taking these medications together.
 
Iron
Iron can decrease the absorption of carbidopa-levodopa-entacapone into the body, perhaps making it less effective. Iron products should be taken at least two hours before or after any carbidopa-levodopa-entacapone dosage.
 
Isoniazid
Isoniazid can make carbidopa-levodopa-entacapone less effective. Check with your healthcare provider before taking these medications together.
 
Medications Metabolized by COMT
Carbidopa-levodopa-entacapone inhibits COMT (catechol-O-methyltransferase), an enzyme that breaks down certain drugs. Carbidopa-levodopa-entacapone could significantly increase the level of such drugs in the body, possibly increasing the risk of dangerous side effects. Check with your healthcare provider before combining carbidopa-levodopa-entacapone with such medications.
(Drug Interactions With Carbidopa-Levodopa-Entacapone Continued: Page 3)

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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;