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Side Effects of Apomorphine

Most people do not have any problems taking apomorphine. Side effects, however, are possible and may include things such as yawning, nausea, and dizziness. While most side effects of apomorphine tend to be minor and are generally easy to treat, more serious side effects can also occur. Contact your healthcare provider if you notice any serious problems, such as chest pain, depression, or an irregular heart rhythm.

An Introduction to Side Effects of Apomorphine

As with any medicine, apomorphine hydrochloride (Apokyn®) may cause side effects. However, not everyone who takes the drug will experience side effects. Many people tolerate it relatively well, at least initially. If side effects do occur, they are often minor and either require no treatment or are easily treated by you or your healthcare provider. However, many people will begin to experience significant and sometimes intolerable apomorphine side effects after several years of use.
(This article covers many, but not all, of the possible side effects with apomorphine. Your healthcare provider can discuss a more complete list of apomorphine side effects with you.)

Serious Side Effects of Apomorphine

Some side effects with apomorphine are potentially serious and should be reported immediately to your healthcare provider. Although most of these serious side effects are rare, a few may be common. Serious side effects of apomorphine include, but are not limited to:
  • Hallucinations or confusion
  • Falling
  • Depression
  • Anxiety
  • Congestive heart failure
  • Fainting
  • Low blood pressure (hypotension)
  • A specific type of irregular heart rhythm (arrhythmia) known as QT prolongation
  • Falling asleep without warning
  • Chest pain or pressure (or other signs of a heart attack)
  • A desire to use apomorphine inappropriately or unnecessarily
  • A painful penile erection that does not go away (known as priapism)
  • Signs of an allergic reaction, including:


    • An unexplained rash
    • Hives
    • Itching
    • Swelling of the mouth or throat
    • Wheezing
    • Difficulty breathing.


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