Drug Interactions With Apomorphine

Certain drug interactions with apomorphine may cause your body to metabolize the drug differently than intended and increase your risk of serious side effects (such as dangerously low blood pressure). Therefore, it is important that your healthcare provider is aware of any other medications you are taking before starting apomorphine. Drug interactions can occur if apomorphine is combined with medications such as blood pressure medications, diuretics, and nitrates.

 

Drug Interactions With Apomorphine: An Overview

Apomorphine hydrochloride (Apokyn®) can potentially interact with several different medications. Some of the medicines that may lead to apomorphine interactions include:
 

 

    • Isosorbide dinitrate (BiDil®, Dilatrate® SR, Isochron™, Isordil®)
    • Isosorbide mononitrate (Imdur®, Ismo®, Monoket®)
    • Nitroglycerin tablets or capsules (NitroQuick®, Nitrostat®, Nitro-Time®)
    • Nitroglycerin ointment (Nitro-Bid®)
    • Nitroglycerin patches (Minitran®, Nitrodisc®, Nitro-Dur®, Transderm-Nitro®, Transderm-NTG®)
    • Nitroglycerin spray (Nitrolingual®)

 

  • 5HT3 antagonists, such as:

 

 

(Drug Interactions With Apomorphine Continued: Page 2)
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Written by/reviewed by: Kristi Monson, PharmD; Arthur Schoenstadt, MD
Last reviewed by: Kristi Monson, PharmD;